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Trovafloxacin 98%

TROVAFLOXACIN

源葉(MedMol)
S29883
147059-72-1
C20H15F3N4O3
416.35
曲伐沙星;曲氟沙星;(1Α,5Α,6Α)-7-(6-氨基-3-氮雜二環[3.1.0]己-3-基)-1-(2,4-二氟苯基)-6-氟-1,4-二氫-4-氧-1,8-萘啶-3-羧酸;特伐沙星;曲氟沙星;TROVAFLOXACIN;1,8-Naphthyridine-3-carboxylic acid, 7-(1.alpha.,5.alpha.,6.alpha.)-6-amin
品牌 貨號 產品規格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數量
源葉(MedMol) S29883-10mg 98% ￥800.00元 預計交期：2-3天 - - -
源葉(MedMol) S29883-50mg 98% ￥2800.00元 1 - - -
產品介紹 參考文獻(1篇) 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1

產品描述：

Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1
靶點： Quinolone;DNAgyrase;Topoisomerase;Antibacterial;Antibiotic
體內研究： Trovafloxacin (150 mg/kg; oral administration; male C57BL/6 J mice) treatment disrupts TNF-induced p65 nuclear translocation. Trovafloxacin treatment increases expression of early NF-κB-related factors A20 and IκBα. Trovafloxacin, when administered in combination with lipopolysaccharide (LPS) or TNF to mice induces severe liver toxicity associated with vast apoptotic areas in the liver, increased serum levels of alanine amino transferases (ALT) and pro-inflammatory cytokines.
參考文獻： 1. Giustarini G, et al. The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. 2. Poon IK, et al. Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature. 2014 Mar 20;507(7492):329-34. 3. Gootz TD, et al. Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob Agents Chemother. 1996 Dec;40(12):2691-7.
溶解性： DMSO  :  10  mg/mL  (24.02  mM;  ultrasonic  and  adjust  pH  to  4  with  HCl)
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.402 ml 12.009 ml 24.018 ml
5 mM 0.48 ml 2.402 ml 4.804 ml
10 mM 0.24 ml 1.201 ml 2.402 ml
50 mM 0.048 ml 0.24 ml 0.48 ml
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