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Quetiapine 98%

Quetiapine

源葉(MedMol)
S80103
111974-69-7
C21H25N3O2S
383.51
品牌 貨號 產(chǎn)品規(guī)格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S80103-10mg 98% ￥227.00元 2 - - -
源葉(MedMol) S80103-50mg 98% ￥630.00元 4 - - -
源葉(MedMol) S80103-100mg 98% ￥990.00元 預計交期：2-3天 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects
產(chǎn)品描述： Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects
靶點： 5-HT1A Receptor:5.74 (pKi);5-HT2A Receptor:7.54 (pKi);5-HT2C Receptor:5.55 (pKi);D2 Receptor:7.25 (pKi);5-HT1A Receptor:4.77 (pEC50);D2 Receptor:6.33 (pIC50);DopamineReceptor;5-HTReceptor;AdrenergicReceptor;AChR;HistamineReceptor
體內(nèi)研究：
Quetiapine (10?mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination
參考文獻：
1. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. 2. Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.
溶解性： Soluble  in  DMSO、H2O、Ethanol
保存條件： 2-8℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.607 ml 13.037 ml 26.075 ml
5 mM 0.521 ml 2.607 ml 5.215 ml
10 mM 0.261 ml 1.304 ml 2.607 ml
50 mM 0.052 ml 0.261 ml 0.521 ml
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參考文獻

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