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HYDROXY ITRACONAZOLE 98%

HYDROXY ITRACONAZOLE

源葉(MedMol)
S80107
112559-91-8
C35H38Cl2N8O5
721.643
品牌 貨號 產品規格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數量
源葉(MedMol) S80107-1mg 98% ￥2000.00元 1 - - -
源葉(MedMol) S80107-5mg 98% ￥6000.00元 2 - - -
產品介紹 參考文獻(1篇) 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

產品描述：

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

靶點： Antifungal
體內研究：
The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view
參考文獻：
1. Mino Y, et al. Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole. Clin Chim Acta. 2013 Jan 16;415:128-32.
溶解性： DMSO  :  100  mg/mL  (138.58  mM;  Need  ultrasonic)    H2O  :  1  mg/mL  (1.39  mM;  ultrasonic  and  warming  and  heat  to  80°C)
保存條件： 2-8℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 1.386 ml 6.929 ml 13.857 ml
5 mM 0.277 ml 1.386 ml 2.771 ml
10 mM 0.139 ml 0.693 ml 1.386 ml
50 mM 0.028 ml 0.139 ml 0.277 ml
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質檢證書(COA)

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批號：C10000001 貨號：A800001-25g
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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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