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IWR-1-endo 99%

IWR-1-endo

源葉(MedMol)
S80108
1127442-82-3
C25H19N3O3
409.44
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫(kù)存（上海） 北京 武漢 南京 購(gòu)買(mǎi)數(shù)量
源葉(MedMol) S80108-5mg 99% ￥280.00元 2 - - -
源葉(MedMol) S80108-10mg 99% ￥480.00元 6 - - -
源葉(MedMol) S80108-25mg 99% ￥1040.00元 2 - - -
源葉(MedMol) S80108-100mg 99% ￥3040.00元 預(yù)計(jì)交期：2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(shū)(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
產(chǎn)品描述： IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
靶點(diǎn)： IC50: 180 nM (Wnt);Wnt/beta-catenin
體外研究：
Both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects in vitro. IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. IWR-1 (10 μM) induces stabilization of β-catenin disruption complex. IWR-1 (10 μM) is added to the medium together with MIF, the size of cell colonies is extremely decreased, and that indicates the promoting effect of MIF on NSPC proliferation is inhibited by IWR-1 in any MIF concentration group. 2, 5 and 10 μM of IWR-1 significantly inhibits the proliferation of NSPC dose-dependently. IWR-1 inhibites the promoting effect of MIF on NSPC differentiation to neuron lineage. IWR-1 treatment in the presence of maximal stimulatory dose of FSH (0.5 ng/mL) results in a dose dependent inhibition of the stimulatory effect of FSH with > 75% inhibition observed at the maximal inhibitory dose of IWR-1 (1 μM). IWR-1 treatment partially reverses the FSH-induced inhibition of granulosa cell CARTPT mRNA expression[
參考文獻(xiàn)：
1. Lu J, et al. Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3825-7. 2. Zhang X, et al. Macrophage migration inhibitory factor promotes proliferation and neuronal differentiation of neural stem/precursor cells through Wnt/β-catenin signal pathway. Int J Biol Sci. 2013 Nov 28;9(10):1108-20. 3. Gupta PS, et al. Regulation and Regulatory Role of WNT Signaling in Potentiating FSH Action during Bovine Dominant Follicle Selection. PLoS One. 2014 Jun 17;9(6):e100201.
溶解性： Soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.442 ml 12.212 ml 24.424 ml
5 mM 0.488 ml 2.442 ml 4.885 ml
10 mM 0.244 ml 1.221 ml 2.442 ml
50 mM 0.049 ml 0.244 ml 0.488 ml
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