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Ramatroban

99%

Ramatroban

產品說明書核磁下載

品牌：源葉(MedMol)

產品編號：S80136

CAS號：116649-85-5

分子式：C₂₁H₂₁FN₂O₄S

分子量：416.466

別名：雷馬曲班;3R-(4-氟苯磺酰氨基)-1,2,3,4-四氫化-9H-咔唑-9-丙酸;3R-[[(4-氟苯基)磺酰]氨基]-1,2,3,4-四氫-9H-咔唑-9-丙酸;BAY-U3405;3R-[[(4-FLUOROPHENYL)SULFONYL]AMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-PROPANOIC ACID;RAMATROBAN;9H-Carbaz

品牌	貨號	產品規格	價格(RMB)	庫存（上海）	北京	武漢	南京
源葉(MedMol)	S80136-5mg	99%	￥300.00元	>10	-	-	-
源葉(MedMol)	S80136-10mg	99%	￥380.00元	10	-	-	-
源葉(MedMol)	S80136-50mg	99%	￥1400.00元	7	-	-	-
源葉(MedMol)	S80136-100mg	99%	￥2380.00元	5	-	-	-

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產品介紹參考文獻質檢證書(COA) 摩爾濃度計算器相關產品

產品介紹

Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.

產品描述：

Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.

靶點：

hTP:14 nM (IC50);hDP2:113 nM (IC50);hDP2:33.4 μM (IC50);GPR;ProstaglandinReceptor;PPAR

體內研究：

Ramatroban is an orally bioavailable small molecule antagonist of CRTH2. Systemic administration of Ramatroban (30 mg/kg) in CRTH2+/+ mice produces the same effects as seen in CRTH2 deficiency. Ramatroban completely blocks LPS-induced decreases in social and object exploratory behavior (p<0.01). In addition, tumor-impaired social interaction and object exploratory behavior in CRTH2+/+ mice are completely reversed by a single injection of Ramatroban, even when the tumor is enlarged

參考文獻：

1. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. 2. Sugimoto H, et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52. 3. Haba R, et al. Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. 2014 Feb 12;34(7):2514-23.

溶解性：

DMSO : 125 mg/mL (300.14 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.401 ml	12.006 ml	24.012 ml
5 mM	0.48 ml	2.401 ml	4.802 ml
10 mM	0.24 ml	1.201 ml	2.401 ml
50 mM	0.048 ml	0.24 ml	0.48 ml

注意：

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參考文獻

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