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產品描述： XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively |
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靶點：
IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation);Tyrosinase;PPAR |
體外研究：
XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87 |
參考文獻：
1. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis. |
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溶解性：
soluble in DMSO |
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保存條件：
-20℃ |
配置溶液濃度參考：
|
1mg |
5mg |
10mg |
| 1 mM |
2.245 ml |
11.223 ml |
22.446 ml |
| 5 mM |
0.449 ml |
2.245 ml |
4.489 ml |
| 10 mM |
0.224 ml |
1.122 ml |
2.245 ml |
| 50 mM |
0.045 ml |
0.224 ml |
0.449 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京