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Mertansine 98%

Mertansine

源葉(MedMol)
S80320
139504-50-0
C35H48ClN3O10S
738.28772
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫(kù)存（上海） 北京 武漢 南京 購(gòu)買數(shù)量
源葉(MedMol) S80320-1mg 98% ￥315.00元 9 - - -
源葉(MedMol) S80320-2mg 98% ￥455.00元 9 - - -
源葉(MedMol) S80320-5mg 98% ￥720.00元 4 - - -
源葉(MedMol) S80320-10mg 98% ￥1230.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S80320-25mg 98% ￥1750.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S80320-50mg 98% ￥2100.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S80320-100mg 98% ￥3500.00元 預(yù)計(jì)交期：2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC)
產(chǎn)品描述： Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC)
靶點(diǎn)： Maytansinoids;MicrotubuleAssociated
體外研究：
Mertansine is a strong antiproliferative chemotherapeutics toward over 60 types of cancer cell lines. Mertansine (0-1 μg/mL) shows antitumor activity in malignant B16F10 melanoma cells, and inhibits tumor cell growth by inhibiting mitosis when combined with DTX. Cell Proliferation Assay Cell Line: Malignant B16F10 melanoma cells Concentration: 0, 0.01, 0.1, and 1 μg/mL Incubation Time: 4 h Result: Showed antitumor activity in malignant B16F10 melanoma cells, with an IC50 of 0.092 μg/mL. Co-delivery of DTX and DM1, both of which inhibit tumor cell growth by inhibiting mitosis, is an effective strategy to achieve a combinatorial anticancer effect.
體內(nèi)研究：
Mertansine (DM1) has a low maximum-tolerated dose (MTD) of 1 mg/kg
參考文獻(xiàn)：
1. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules. 2. Lopus M. Antibody-DM1 conjugates as cancer therapeutics. Cancer Lett. 2011 Aug 28;307(2):113-8. 3. Zhong P, et al. cRGD-installed docetaxel-loaded mertansine prodrug micelles: redox-triggered ratiometric dual drug release and targeted synergistic treatment of B16F10 melanoma. Nanotechnology. 2017 Jul 21;28(29):295103.
溶解性： soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 1.354 ml 6.772 ml 13.545 ml
5 mM 0.271 ml 1.354 ml 2.709 ml
10 mM 0.135 ml 0.677 ml 1.354 ml
50 mM 0.027 ml 0.135 ml 0.271 ml
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參考文獻(xiàn)

質(zhì)檢證書(COA)

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