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產品描述： Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist that induces the upregulation of cytokines such as TNF-α, IL-6 and IFN-α. |
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靶點：
TLR7;TLR8;HCVProtease;TLR |
體內研究：
Resiquimod (R-848) (50 μg/bird, i.m. route) significantly up-regulates the expression of IFN-α, IFN-β, IFN-γ, IL-1β, IL-4, iNOS and MHC-II genes in SPF chicken |
參考文獻：
1. Sachan S, et al. Adjuvant potential of resiquimod with inactivated Newcastle disease vaccine and its mechanism of action in chicken. Vaccine. 2015 Aug 26;33(36):4526-32. 2. Brugnolo F, et al. The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells. J Allergy Clin Immunol. 2003 Feb;111(2):380-8. 3. Zhou ZX, et al. Immune effects of R848: evidences that suggest an essential role of TLR7/8-induced, Myd88- and NF-κB-dependent signaling in the antiviral immunity of Japanese flounder (Paralichthys olivaceus). Dev Comp Immunol. 2015 Mar;49(1):113-20. |
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溶解性：
DMF : 50 mg/mL (159.04 mM; Need ultrasonic) DMSO : ≥ 30 mg/mL (95.43 mM) Methanol : 25 mg/mL (79.52 mM; Need ultrasonic) H2O : 0.1 mg/mL (0.32 mM; Need ultrasonic) |
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保存條件：
-20℃ |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
3.181 ml |
15.904 ml |
31.808 ml |
| 5 mM |
0.636 ml |
3.181 ml |
6.362 ml |
| 10 mM |
0.318 ml |
1.59 ml |
3.181 ml |
| 50 mM |
0.064 ml |
0.318 ml |
0.636 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京