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  1. 首頁 > 小分子化合物 > 信號(hào)通路 > 蛋白酶體 > CA-074 ME

CA-074 ME 98%

CA-074 ME

源葉(MedMol)
S80376
147859-80-1
C19H31N3O6
397.466
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S80376-1mg 98% ￥400.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S80376-5mg 98% ￥748.00元 4 - - -
源葉(MedMol) S80376-25mg 98% ￥2461.60元 5 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.
產(chǎn)品描述： CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.
靶點(diǎn)： Cathepsin;CysteineProtease
體內(nèi)研究：
Hippocampal CA1 neuronal programmed necrosis induced by global cerebral I/R injury is prevented by CA074-me (1 μg, 10 μg) both pre-treatment and post-treatment. The rupture of lysosomal membrane and the leakage of cathepsin-B, and this is strongly inhibited by CA074-me pre-treatment. The overexpression and nuclear translocation of RIP3 and the reduction of NAD+ level after I/R injury are also inhibited, while the upregulation of Hsp70 is strengthened by CA074-me pre-treatment. CA-074Me (30 mg/kg) is capable of inhibiting osteoclastogenesis and bone degradation in vivo. In the CVB+CA-074Me (4 mg/kg/day i.m.) guinea pigs group, the scores of inflammation significantly decrease in comparison with the CVB+None group. In CVB+CA-074Me group, the number of CD8+T cells decrease in comparison with the sham group
參考文獻(xiàn)：
1. Xu Y, et al. Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats. Brain Res Bull. 2016 Jan;120:97-105 2. Patel N, et al. CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-FOS signaling pathways. J Orthop Res. 2015 Oct;33(10):1474-86 3. Zhang L, et al. Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis. Lab Invest. 2015 Jan;95(1):65-77
溶解性： DMSO  :  100  mg/mL  (251.59  mM;  Need  ultrasonic)    H2O  :  <  0.1  mg/mL  (ultrasonic;warming;heat  to  60°C)  (insoluble)
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.516 ml 12.58 ml 25.159 ml
5 mM 0.503 ml 2.516 ml 5.032 ml
10 mM 0.252 ml 1.258 ml 2.516 ml
50 mM 0.05 ml 0.252 ml 0.503 ml
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參考文獻(xiàn)

質(zhì)檢證書(COA)

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