| 產品描述： | Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface |
| 靶點： |
αvβ3:0.94 nM (IC50);Integrin |
| 參考文獻： |
1. Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95. 2. Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14. |
| 溶解性： |
DMSO : 125 mg/mL (207.07 mM; Need ultrasonic) H2O : 50 mg/mL (82.83 mM; Need ultrasonic) |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.657 ml |
8.283 ml |
16.565 ml |
| 5 mM |
0.331 ml |
1.657 ml |
3.313 ml |
| 10 mM |
0.166 ml |
0.828 ml |
1.657 ml |
| 50 mM |
0.033 ml |
0.166 ml |
0.331 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京