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Efaproxiral sodium 98%

Efaproxiral sodium

源葉(MedMol)
S80455
170787-99-2
C20H22NNaO4
363.383
品牌 貨號 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S80455-10mg 98% ￥186.00元 >10 - - -
源葉(MedMol) S80455-50mg 98% ￥410.00元 6 - - -
源葉(MedMol) S80455-200mg 98% ￥1250.00元 3 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Efaproxiral Sodium , a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.
產(chǎn)品描述： Efaproxiral Sodium , a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.
靶點(diǎn)： Reactive Oxygen Species;ReactiveOxygenSpecies
體內(nèi)研究：
Efaproxiral plus oxygen breathing reduces the radiobiological hypoxic fraction of EMT6 tumors from the value of 24% found in both air-breathing and oxygen-breathing mice to 9% and improves the response of the tumors to radiation. Carboplatin (100 mg/kg) slowes tumor growth in air-breathing mice, producing a growth delay of 3.3 days. Efaproxiral plus oxygen increases the growth delay to 5.7 days; this is 2.4 days (71%) greater than that for carboplatin alone and 2.1 days (57%) greater than that for carboplatin plus oxygen breathing. Efaproxiral plus oxygen breathing, therefore, improves the tumor growth delay obtained with 100 mg/kg carboplatin to or beyond that obtained with the highly toxic dose of 150 mg/kg carboplatin, but does so without increasing the toxicity beyond that seen with 100 mg/kg carboplatin in air-breathing mice. Efaproxiral significantly increases tumor oxygenation by 8.4 to 43.4 mmHg within 5 days in C3H mice with RIF-1 tumors, with maximum increases at 22-31 min after treatment. Efaproxiral plus oxygen plus Radiation produces tumor growth inhibition throughout the treatment duration in C3H mice with RIF-1 tumors, and inhibition is significantly different from radiation plus oxygen from day 3 to day 5.
參考文獻(xiàn)：
1.Donnelly ET, et al. Exp Biol Med (Maywood), 2006, 231(3), 317-321. 2.Hou H, et al. Radiat Res, 2007, 168(2), 218-225.
溶解性： H2O:67  mg/mL  (184.4  mM)    DMSO:68  mg/mL  (187.1  mM)    Ethanol:68  mg/mL  (187.1  mM)
保存條件： 2-8℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.752 ml 13.76 ml 27.519 ml
5 mM 0.55 ml 2.752 ml 5.504 ml
10 mM 0.275 ml 1.376 ml 2.752 ml
50 mM 0.055 ml 0.275 ml 0.55 ml
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