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KB-R7943 mesylate

    
98%

2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate

源葉(MedMol)
S80482 一鍵復(fù)制產(chǎn)品信息
182004-65-5
C17H21N3O6S2
427.495
KB-R7943 甲磺酸鹽; 2-[2-[4-(4-硝基芐氧基)苯基]乙基]異硫脲甲烷磺; S-[4-[(4-硝基芐基)氧代]苯乙基]異硫脲甲磺酸鹽;;Carbamimidothioic Acid 4-[(4-Nitrobenzyl)oxy]phenethyl Ester Methanesulfonate; KB-R7943 mesylate; 4-[(4-Nitrobenzyl)oxy]phen
貨號(hào) 規(guī)格 價(jià)格 上海 北京 武漢 南京 購買數(shù)量
S80482-5mg 98% ￥320.00 4 - - -
S80482-10mg 98% ￥480.00 10 - - -
S80482-50mg 98% ￥1200.00 >10 - - -
產(chǎn)品介紹 參考文獻(xiàn)(1篇) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.

產(chǎn)品描述： KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.
靶點(diǎn)： IC50: 5.7±2.1 μM (Na+/Ca2+?exchanger);Na+/Ca2+Exchanger;Autophagy
參考文獻(xiàn)： 1. Brustovetsky T, et al. KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I. Br J Pharmacol. 2011 Jan;162(1):255-70. 2. Barrientos G, et al. The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate(KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Mol Pharmacol. 2009 Sep;76(3):560-8. 3. Cheng H, et al. High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943. Br J Pharmacol. 2012 Apr;165(7):2260-73. 4. Long Z, et al. The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux. Oncotarget. 2016;7(27):42059-70.
溶解性： DMSO  :  100  mg/mL  (233.92  mM;  Need  ultrasonic)
保存條件： 2-8℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.339 ml 11.696 ml 23.392 ml
5 mM 0.468 ml 2.339 ml 4.678 ml
10 mM 0.234 ml 1.17 ml 2.339 ml
50 mM 0.047 ml 0.234 ml 0.468 ml
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質(zhì)檢證書(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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摩爾濃度計(jì)算器

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