| 產品描述： | Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM |
| 靶點： |
Parasite;Chloride Channel;P-glycoprotein;Bacterial;Chloridechannel;P-gp;Parasite |
| 體內研究： |
A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae |
| 參考文獻： |
1. Patsharaporn T Sarasombath, et al. First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions. Parasitol Res. 2019 Apr;118(4):1289-1297. 2. J Griffin, et al. Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein. J Vet Pharmacol Ther. 2005 Jun;28(3):257-65. |
| 溶解性： |
DMSO : ≥ 100 mg/mL (129.88 mM) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.299 ml |
6.494 ml |
12.988 ml |
| 5 mM |
0.26 ml |
1.299 ml |
2.598 ml |
| 10 mM |
0.13 ml |
0.649 ml |
1.299 ml |
| 50 mM |
0.026 ml |
0.13 ml |
0.26 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京