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SEA0400 99%

SEA0400

源葉(MedMol)
S80552
223104-29-8
C21H19F2NO3
371.38
品牌 貨號 產(chǎn)品規(guī)格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S80552-1mg 99% ￥280.00元 >10 - - -
源葉(MedMol) S80552-5mg 99% ￥850.00元 >10 - - -
源葉(MedMol) S80552-10mg 99% ￥1500.00元 >10 - - -
源葉(MedMol) S80552-25mg 99% ￥2400.00元 >10 - - -
源葉(MedMol) S80552-100mg 99% ￥5600.00元 5 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.
產(chǎn)品描述： SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.
靶點： IC50: 5-33 nM (NCX);CalciumChannel;Na+/Ca2+Exchanger
體內(nèi)研究：
SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats[1]. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice
參考文獻：
1. Matsuda T, et al. SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther. 2001 Jul;298(1):249-56. 2. Nashida T, et al. The specific Na(+)/Ca(2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Neurochem Int. 2011 Aug;59(1):51-8. 3. Ago Y, et al. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. Neuropharmacology. 2011 Dec;61(8):1441-51.
溶解性： Soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.693 ml 13.463 ml 26.927 ml
5 mM 0.539 ml 2.693 ml 5.385 ml
10 mM 0.269 ml 1.346 ml 2.693 ml
50 mM 0.054 ml 0.269 ml 0.539 ml
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參考文獻

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