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CFTRinh-172

    
98%

CFTRinh-172

源葉(MedMol)
S80615 一鍵復制產品信息
307510-92-5
C18H10F3NO3S2
409.4
3-[(3-三氟甲基)苯基]-5-[(4-羧基苯基)亞甲基]-2-硫代-4-噻唑烷酮;CFTR(INH)-172;CFTR INHIBITOR-172;5-[(4-CARBOXYPHENYL)METHYLENE]-2-THIOXO-3-[(3-TRIFLUOROMETHYL)PHENYL-4-THIAZOLIDINONE];3-[(3-TRIFLUOROMETHYL)PHENYL]-5-[(4-C
貨號 規格 價格 上海 北京 武漢 南京 購買數量
S80615-2mg 98% ¥288.00 7 - - -
S80615-5mg 98% ¥360.00 8 - - -
S80615-10mg 98% ¥450.00 7 - - -
S80615-50mg 98% ¥1200.00 7 - - -
S80615-100mg 98% ¥1900.00 4 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.

產品描述: CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.
靶點: Ki: 300 nM (CFTR);CFTR;Autophagy
體內研究: A single intraperitoneal injection of CFTR(inh)-172 (250 μg/kg) in mice reduces by more than 90% cholera toxin–induced fluid secretion in the small intestine over 6 hours. CFTR(inh)-172 is nontoxic at high concentrations in mouse models. CFTRinh-172 significantly reduces fluid secretion to that in saline control loops, whereas an inactive CFTRinh-172 analog does not inhibit fluid secretion
參考文獻: 1. Ma T, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec;110(11):1651-8. 2. Taddei A, et al. Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker. FEBS Lett. 2004 Jan 30;558(1-3):52-6.
溶解性: DMSO  :  50  mg/mL  (122.13  mM;  Need  ultrasonic)
保存條件: 2-8℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 2.443 ml 12.213 ml 24.426 ml
5 mM 0.489 ml 2.443 ml 4.885 ml
10 mM 0.244 ml 1.221 ml 2.443 ml
50 mM 0.049 ml 0.244 ml 0.489 ml
注意: 部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

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批號:JS298415 貨號:S20001-25g
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摩爾濃度計算器

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