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TRx0237 mesylate 98%

Leucomethylene blue (Mesylate)

源葉(MedMol)
S81261
1236208-20-0
C18H27N3O6S3
477.6185
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S81261-5mg 98% ￥240.00元 4 - - -
源葉(MedMol) S81261-10mg 98% ￥400.00元 5 - - -
源葉(MedMol) S81261-25mg 98% ￥800.00元 4 - - -
源葉(MedMol) S81261-100mg 98% ￥2400.00元 3 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
產(chǎn)品描述： TRx 0237 (LMTX) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
靶點(diǎn)： Tau aggregation;BetaAmyloid;?MicrotubuleAssociated
體外研究：
TRx 0237 (LMTX?) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions[2]. An in vitro study showed the ability of TRx 0237 in disrupting PHFs(paired helical filaments) isolated from Alzheimer's Disease brain tissues at the concentration at 0.16 μM。
體內(nèi)研究：
TRx 0237 dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66。
參考文獻(xiàn)：
1. LMTM. THERAPEUTICS overview. 2. Panza F, et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy?. Expert Opin Pharmacother. 2016, 17(4):457-61. 3. Gui W, Xu S, Dang Z, et al. In Vitro and in Vivo Effect of Mapk Signal Transduction Pathway Inhibitors on Echinococcus multilocularis[J]. Journal of Parasitology. 2019 Feb;105(1):146-154. 4. Liu Z, Wang F, Tang M, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A (1) receptor[J]. International journal of molecular medicine. 2019 Jan;43(1):435-442.
溶解性： Soluble  in  DMSO、H2O
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.094 ml 10.469 ml 20.937 ml
5 mM 0.419 ml 2.094 ml 4.187 ml
10 mM 0.209 ml 1.047 ml 2.094 ml
50 mM 0.042 ml 0.209 ml 0.419 ml
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