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產品描述： UNC 669, a ligand for a methyl-lysine binding domain, is a potent L3MBTL1 (IC50=4.2 uM) and L3MBTL3 (3.1 uM) inhibitor |
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靶點：
IC50: 4.2 uM/3.1 uM (L3MBTL1/L3MBTL3);EpigeneticReaderDomain |
參考文獻：
1. James LI, et al. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. J Med Chem. 2013 Sep 26;56(18):7358-71. 2. Trojer P, et al. L3MBTL1, a histone-methylation-dependent chromatin lock. Cell. 2007;129(5):915-928. 3. Baughman BM, et al. The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer [retracted in: ACS Chem Biol. 2018 Jan 19;13(1):281]. ACS Chem Biol. 2016;11(3):722-728. |
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溶解性：
DMSO : 50 mg/mL (147.82 mM; Need ultrasonic) |
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保存條件：
RT |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
2.956 ml |
14.782 ml |
29.565 ml |
| 5 mM |
0.591 ml |
2.956 ml |
5.913 ml |
| 10 mM |
0.296 ml |
1.478 ml |
2.956 ml |
| 50 mM |
0.059 ml |
0.296 ml |
0.591 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京