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產品描述： KPT-276 is an orally bioavailable selective inhibitor of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of CRM1. |
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靶點：
CRM1 |
體內研究：
KPT-276 significantly prolongs survival of leukemic mice and reduces leukemic burden in a xenograft AML mouse model. KPT-276 significantly suppresses tumor growth in an MCL-bearing severe combined immunodeficient mouse model without severe toxicity. KPT-276 reduces monoclonal spikes in the Vk*MYC transgenic MM mouse model, and inhibits tumor growth in a xenograft MM mouse model. |
參考文獻：
1.Ranganathan P, et al. Blood. 2012, 120(9), 1765-1773. 2.Schmidt J, et al. Leukemia. 2013, 27(12), 2357-2365. 3.Azmi AS, et al. Exp Hematol. 2013, 41(1), 67-78. |
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溶解性：
H2O:<1 mg/mL Ethanol:<1 mg/mL DMSO:16 mg/mL (37.5 mM) |
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保存條件：
-20℃ |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
2.346 ml |
11.73 ml |
23.46 ml |
| 5 mM |
0.469 ml |
2.346 ml |
4.692 ml |
| 10 mM |
0.235 ml |
1.173 ml |
2.346 ml |
| 50 mM |
0.047 ml |
0.235 ml |
0.469 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京