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產品描述： Oxfendazole, a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms. |
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靶點：
Glucokinase;Microtubule Associated;Parasite;Glucokinase;?MicrotubuleAssociated;?Parasite |
體內研究：
Oxfendazole (OX) induces not only mRNA expression of phase I enzymes Cyp1a1, Cyp1a2, but also Nrf2-regulated phase II enzymes such as Gpx2, Nqo1, Yc2, Akr7a3 and Gstm1 in rats, presumably due to an adaptive response against OX-induced oxidative stress. Oxfendazole enhances oxidative DNA damage (as assessed by 8-hydroxydeoxyguanosine; 8-OHdG) and lipid peroxidation (as assessed by thiobarbituric acid-reactive substances; TBARS) in rats. Oxfendazole administered at the therapeutic dose (4.5 mg/kg) and at the highest dose (22.5 mg/kg) increase 1.54- and 2.36-fold the total liver microsomal cytochrome P450 and more particularly the isoenzyme P450IA2 (95% and 184% increases) in rabbit liver. Oxfendazole MRL induces a mutagenic effect in all tested cell types. Oxfendazole exhibits embryotoxicity including teratogenicity. Oxfendazole induces a disturbance in the different biochemical contents of all tested tissues in mice. Oxfendazole increases the incidence and multiplicity of altered foci (4.0- and 3.6-fold, respectively) and hepatocellular adenomas (HCAs) (3.0- and 5.5-fold, respectively). Oxfendazole treatment induces 5.2- and 5.6-fold increases in the number of proliferating cell nuclear antigen (PCNA)-positive cells and single-stranded DNA (ssDNA)-positive cells in HCAs compared with the surrounding tissue, respectively. Oxfendazole and its sulphone metabolite attain a significantly higher plasma concentration and remain much longer in plasma compared with fenbendazole (FBZ) and albendazole (ABZ) and |
參考文獻：
1.Dewa Y, et al. Arch Toxicol,2009, 83(5), 503-511. 2.Dewa Y, et al. Arch Toxicol,2011, 85(2), 155-162. 3.El-Makawy A, et al. Reprod Nutr Dev,2006, 46(2), 139-156. 4.Gokbulut C, et al. Vet Parasitol,2007, 148(3-4), 279-287. 5.Gleizes C, et al. Biochem Pharmacol,1991, 41(12), 1813-1820. |
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溶解性：
Ethanol:<1 mg/mL H2O:<1 mg/mL DMSO:10 mg/mL (31.71 mM) |
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保存條件：
2-8℃ |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
3.171 ml |
15.855 ml |
31.711 ml |
| 5 mM |
0.634 ml |
3.171 ml |
6.342 ml |
| 10 mM |
0.317 ml |
1.586 ml |
3.171 ml |
| 50 mM |
0.063 ml |
0.317 ml |
0.634 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京