| 產品描述： | Ethosuximide is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures. |
| 靶點： |
calcium channel |
| 體內研究： |
Anti-epileptic drug ethosuximide rescues the short lifespan and chemosensory defects exhibited by C. elegans null mutants of dnj-14, the worm orthologue of the DNAJC5 gene mutated in autosomal-dominant adult-onset neuronal ceroid lipofuscinosis. It also ameliorates the locomotion impairment and short lifespan of worms expressing a human Tau mutant that causes frontotemporal dementia. Ethosuximide extends lifespan by inhibiting the function of specific chemosensory neurons. It increases neurogenesis, reduces neurodegeneration, and reverses cognitive impairments in rat model of AD like phenotypes |
| 細胞實驗： |
Mouse Neuro2A (N2A) neuroblastoma cells are cultured on 6-well plates and treated with retinoic acid to induce neuronal differentiation. After 24 h, N2A cells are treated with vehicle control (PBS) or increasing concentrations of ethosuximide for 5 h. Total RNA is then isolated, DNase-treated and reverse transcribed to cDNA. qRT-PCR is run above normalising to the reference genes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin (ACTB). (Only for Reference) |
| 參考文獻： |
1.Coulter DA, et al. Ann Neurol. 1989, 25(6):582-93. 2.Tiwari SK, et al. J Biol Chem. 2015, 290(47):28540-28558. 3.Collins JJ, et al. PLoS Genet. 2008, 4(10):e120200230. 4.Chen X, et al. Mol Neurodegener. 2015, 10:51. |
| 溶解性： |
H2O:198.3 mM DMSO:198.3 mM |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
7.084 ml |
35.418 ml |
70.837 ml |
| 5 mM |
1.417 ml |
7.084 ml |
14.167 ml |
| 10 mM |
0.708 ml |
3.542 ml |
7.084 ml |
| 50 mM |
0.142 ml |
0.708 ml |
1.417 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京