產品描述: P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with an EC50 of 4.2 μM. |
靶點:
EC50: 4.2 μM (USP7) |
體內研究:
In animal tumor model studies, P005091 is well tolerated, inhibits tumor growth, and prolongs survival. Combining P005091 with lenalidomide, HDAC inhibitor SAHA, or dexamethasone triggers synergistic anti-MM activity |
參考文獻:
1. Chauhan D, et al. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Cancer Cell. 2012 Sep 11;22(3):345-58. |
溶解性:
1-Methyl-2-pyrrolidinone : 100 mg/mL (287.17 mM; Need ultrasonic) DMSO : 25 mg/mL (71.79 mM; Need ultrasonic) |
保存條件:
2-8℃ |
配置溶液濃度參考:
|
1mg |
5mg |
10mg |
1 mM |
2.872 ml |
14.359 ml |
28.717 ml |
5 mM |
0.574 ml |
2.872 ml |
5.743 ml |
10 mM |
0.287 ml |
1.436 ml |
2.872 ml |
50 mM |
0.057 ml |
0.287 ml |
0.574 ml |
|
注意: |
部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。 |