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Lifitegrast 99%

Lifitegrast

源葉(MedMol)
S81722
1025967-78-5
C29H24Cl2N2O7S
615.4811
品牌 貨號 產品規格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數量
源葉(MedMol) S81722-1mg 99% ￥100.00元 2 - - -
源葉(MedMol) S81722-2mg 99% ￥180.00元 1 - - -
源葉(MedMol) S81722-5mg 99% ￥280.00元 4 - - -
源葉(MedMol) S81722-10mg 99% ￥320.00元 >10 - - -
源葉(MedMol) S81722-25mg 99% ￥370.00元 4 - - -
源葉(MedMol) S81722-50mg 99% ￥600.00元 5 - - -
源葉(MedMol) S81722-100mg 99% ￥1000.00元 5 - - -
產品介紹 參考文獻(1篇) 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease
產品描述： Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease
靶點： αLβ2;Integrin
體外研究：
Lifitegrast (SAR 1118) inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses. Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM
體內研究：
Lifitegrast (SAR 1118), has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior. Lifitegrast (SAR 1118) ophthalmic drops administered thrice daily deliver therapeutic levels of Lifitegrast (SAR 1118) in the retina and can alleviate the retinal complications associated with diabetes
參考文獻：
1. Perez VL, et al. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 Apr;14(2):207-15. 2. Sun Y, et al. Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther. 2013 May;29(4):395-402. 3. Rao VR, et al. Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin(STZ) model of diabetic retinopathy (DR). Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5198-204.
溶解性： soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 1.625 ml 8.124 ml 16.247 ml
5 mM 0.325 ml 1.625 ml 3.249 ml
10 mM 0.162 ml 0.812 ml 1.625 ml
50 mM 0.032 ml 0.162 ml 0.325 ml
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摩爾濃度計算器

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