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Dafadine-A

    
98%

Dafadine-A

源葉(MedMol)
S81865 一鍵復制產(chǎn)品信息
1065506-69-5
C23H25N3O3
391.4629
貨號 規(guī)格 價格 上海 北京 武漢 南京 購買數(shù)量
S81865-5mg 98% ￥500.00 貨期：2-3天 - - -
S81865-10mg 98% ￥730.00 貨期：2-3天 - - -
S81865-50mg 98% ￥2920.00 貨期：2-3天 - - -
產(chǎn)品介紹 參考文獻 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1). IC50 value: Target: DAF-9(CYP27A1) inhibitor The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.

產(chǎn)品描述： Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1). IC50 value: Target: DAF-9(CYP27A1) inhibitor The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematodeCaenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.
靶點： Cytochrome P450;P450
參考文獻： 1. Luciani GM, et al. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Nov 6;7(12):891-3.
溶解性： soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.555 ml 12.773 ml 25.545 ml
5 mM 0.511 ml 2.555 ml 5.109 ml
10 mM 0.255 ml 1.277 ml 2.555 ml
50 mM 0.051 ml 0.255 ml 0.511 ml
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參考文獻

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