產(chǎn)品描述: | ERK5-IN-1 is a potent ERK5 inhibitor with an IC50 of 87±7 nM. ERK5-IN-1 also inhibits LRRK2[G2019S] with an IC50 of 26 nM. |
靶點(diǎn): |
ERK5:87 nM (IC50);LRRK2[G2019S]:26 nM (IC50);ERK |
體外研究: |
ERK5-IN-1 (Compound 5) exhibits a cellular EC50 for inhibiting epidermal growth factor (EGF) induced ERK5 autophosphorylation of 0.19±0.04 μM |
參考文獻(xiàn): |
1. Deng X, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. Eur J Med Chem. 2013;70:758-767. |
溶解性: |
Soluble in DMSO |
保存條件: |
-20℃ |
配置溶液濃度參考: |
|
1mg |
5mg |
10mg |
1 mM |
2.176 ml |
10.88 ml |
21.761 ml |
5 mM |
0.435 ml |
2.176 ml |
4.352 ml |
10 mM |
0.218 ml |
1.088 ml |
2.176 ml |
50 mM |
0.044 ml |
0.218 ml |
0.435 ml |
|
注意: |
部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。 |