亚洲依依成人综合网站,手机看片国内基地,日本性爱视频大全在线观看,秋水一色性福利导航,欧美A级V片在线观看,韩国论理片,欧美特色AAA大片,6一12泑女WWW,肥臀喷水上位

Entacapone

99%

Entacapone

產(chǎn)品說(shuō)明書(shū) 核磁下載

品牌：源葉(MedMol)

產(chǎn)品編號(hào)：S82780 一鍵復(fù)制產(chǎn)品信息

CAS號(hào)：130929-57-6

分子式：C₁₄H₁₅N₃O₅

分子量：305.29

別名：恩他卡朋;(E)-2-氰基-3-(3,4二羥基-5-硝基苯)-N,N二乙基丙烯酰胺

貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S82780-5mg	99%	￥208.00 S82780-5mg ￥208.00 現(xiàn)貨	1 1	-	-	-
S82780-10mg	99%	￥360.00 S82780-10mg ￥360.00 現(xiàn)貨	6 6	-	-	-
S82780-25mg	99%	￥680.00 S82780-25mg ￥680.00 現(xiàn)貨	1 1	-	-	-
S82780-50mg	99%	￥1120.00 S82780-50mg ￥1120.00 現(xiàn)貨	7 7	-	-	-
S82780-100mg	99%	￥1680.00 S82780-100mg ￥1680.00 現(xiàn)貨	3 3	-	-	-

大包裝詢(xún)價(jià)

加入購(gòu)物車(chē)

產(chǎn)品介紹參考文獻(xiàn)(3篇) 質(zhì)檢證書(shū)(COA) 摩爾濃度計(jì)算器相關(guān)產(chǎn)品

產(chǎn)品介紹

Entacapone (OR-611) 抑制兒茶酚-O-甲基轉(zhuǎn)移酶(COMT)活性，IC50為151 nM。Entacapone 是一種 FTO demethylation 的抑制劑，IC50為3.5 μM，可用于代謝紊亂的研究

產(chǎn)品描述：

Entacapone (OR-611) 抑制兒茶酚-O-甲基轉(zhuǎn)移酶(COMT)活性，IC50為151 nM。Entacapone 是一種 FTO demethylation 的抑制劑，IC50為3.5 μM，可用于代謝紊亂的研究

靶點(diǎn)：

COMT:151 nM;Transferase

體外研究：

Entacapone在不同組織中抑制catechol-O-methyltransferase(COMT)的IC50值大體相似，包括肝臟，十二指腸, 腎臟和肺, 但是entacapone在這些組織中抑制效果比tolcapone更好。 Entacapone (< 100 μM)可以有效抑制α-syn和β-amyloid (Aβ) 齊聚反應(yīng)和原纖維生成同時(shí)可以保護(hù)PC12細(xì)胞免受這兩種蛋白聚集誘導(dǎo)的細(xì)胞外毒性

體內(nèi)研究：

Entacapone administration reduced body weight and lowered fasting blood glucose concentrations in diet-induced obese mice.

細(xì)胞實(shí)驗(yàn)：

Cell lines: PC12 cells Concentrations: 5 μM Incubation Time: 72 h Method: Cells were treated with various concentrations of drug for 72 h.

動(dòng)物實(shí)驗(yàn)：

Animal Models: Male C57BL/6 mice Dosages: 600 mg/kg Administration: p.o.

參考文獻(xiàn)：

1. De Santi C, et al. Catechol-O-methyltransferase: variation in enzyme activity and inhibition by entacapone and tolcapone. Eur J Clin Pharmacol, 1998, 54(3), 215-219. 2. Di Giovanni S, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem, 2010, 285(20), 14941-14954. 3. Jenner P, et al. Avoidance of dyskinesia: preclinical evidence for continuous dopaminergic stimulation. Neurology, 2004, 62(1 Suppl 1), S47-55. 4. Hamaue N, et al. Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus. Brain Res, 2010, 1309, 110-115. 5. Peng S, et al. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med. 2019 Apr 17;11(488):eaa

溶解性：

Soluble in DMSO、Ethanol

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.276 ml	16.378 ml	32.756 ml
5 mM	0.655 ml	3.276 ml	6.551 ml
10 mM	0.328 ml	1.638 ml	3.276 ml
50 mM	0.066 ml	0.328 ml	0.655 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

參考文獻(xiàn)(3篇)

3. [IF=2.9] Nan Zhang et al."N6-methyladenosine mediated-NRF2 signaling pathway attenuates cadmium cytotoxicity by inhibiting oxidative damage in bronchial epithelial cells."TOXICOLOGY LETTERS.2025 Jan;403:144 2. [IF=4.8] Guofen Liu et al."Roles of N6-methyladenosine in LncRNA changes and oxidative damage in cadmium-induced pancreatic β-cells."TOXICOLOGY.2025 Feb;511:154053 1. [IF=6.2] Yifei Sun et al."Roles of m6A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Sep;282:116672

質(zhì)檢證書(shū)(COA)

輸入產(chǎn)品批號(hào)：

如何獲取質(zhì)檢證書(shū)(COA)?

請(qǐng)輸入貨號(hào)和一個(gè)與之匹配的批號(hào)。
例如:
批號(hào)：JS298415 貨號(hào)：S20001-25g
在貨品標(biāo)簽上如何找到貨號(hào)和批號(hào)?

摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計(jì)算重置