| 產品描述： | VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V. |
| 靶點： |
Cysteine Protease;CysteineProtease |
| 體外研究： |
VBY-825 is a potent assayed cathepsins inhibitor and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines. |
| 參考文獻： |
1. Elie BT, et al. Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model. Biochimie. 2010 Nov;92(11):1618-24. |
| 溶解性： |
soluble in DMSO |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.867 ml |
9.336 ml |
18.672 ml |
| 5 mM |
0.373 ml |
1.867 ml |
3.734 ml |
| 10 mM |
0.187 ml |
0.934 ml |
1.867 ml |
| 50 mM |
0.037 ml |
0.187 ml |
0.373 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京