| 產(chǎn)品描述： | MK2-IN-1 is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM) |
| 靶點(diǎn)： |
MAPK |
| 體外研究： |
MK2-IN-1 has been shown to inhibit pro-inflammatory cytokine secretion from the human THP-1 acute monocytic leukemia cell line, causing inhibition of LPS-stimulated TNF-α (IC50: 4.4 μM) and IL-6 (IC50: 5.2 μM) secretion.1 It can also inhibit IL-1β-stimulated matrix-metalloprotease 13 secretion from the SW1353 chondrosarcoma cell line (IC50: 5.7 μM) and human primary chondrocyte cultures (IC50: 2.2 μM) |
| 參考文獻(xiàn)： |
1. Huang X, Shipps Jr G W, Cheng C C, et al. Discovery and hit-to-lead optimization of non-ATP competitive MK2 (MAPKAPK2) inhibitors[J]. ACS medicinal chemistry letters, 2011, 2(8): 632-637. |
| 溶解性： |
soluble in DMSO |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.963 ml |
9.815 ml |
19.63 ml |
| 5 mM |
0.393 ml |
1.963 ml |
3.926 ml |
| 10 mM |
0.196 ml |
0.981 ml |
1.963 ml |
| 50 mM |
0.039 ml |
0.196 ml |
0.393 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險(xiǎn)品化學(xué)品經(jīng)營(yíng)許可證（不帶存儲(chǔ)）
營(yíng)業(yè)執(zhí)照(三證合一)
北京