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BM212

    
99%

BM212

源葉(MedMol)
S83420 一鍵復制產品信息
146204-42-4
C23H25Cl2N3
414.3707
UNII-U9HSU4GZWL; BM212;
貨號 規格 價格 上海 北京 武漢 南京 購買數量
S83420-1mg 99% ¥290.00 10 - - -
S83420-5mg 99% ¥730.00 5 - - -
S83420-10mg 99% ¥1030.00 5 - - -
S83420-50mg 99% ¥2320.00 2 - - -
S83420-100mg 99% ¥3150.00 貨期:2-3天 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 μM

產品描述: BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 μM
靶點: M. tuberculosis;Antibacterial
體外研究: BM212 (2 μg/mL and 8 μg/mL) leads to major structural changes in the cell of M. abscessus CIP104536T S and R variants and results in the complete loss of the hydrophobic nanodomains observed on S cells but no significantly affect on R cells at dose of 2 μg/mL. BM212 (0.5-10 μg/mL, 7 days) inhibits the activity of Mycobacterium avium in U937 cells in a dose-dependent manner with a MIC of 0.5 μg/mL and 100% inhibition starting at a concentration of 1 μg/mL
參考文獻: 1. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7. 2. Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2) 3. Albertus Viljoen, et al. Fast chemical force microscopy demonstrates that glycopeptidolipids define nanodomains of varying hydrophobicity on mycobacteria. Nanoscale Horiz. 2020 Jun 1;5(6):944-953. 4. Delia Deidda, et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7.
溶解性: Soluble  in  DMSO、Ethanol
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 2.413 ml 12.066 ml 24.133 ml
5 mM 0.483 ml 2.413 ml 4.827 ml
10 mM 0.241 ml 1.207 ml 2.413 ml
50 mM 0.048 ml 0.241 ml 0.483 ml
注意: 部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

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