產品描述: MMAD is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugates (ADCs). |
靶點:
Auristatin;MicrotubuleAssociated |
體內研究:
The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats |
參考文獻:
1. Chudasama V, et al. Recent advances in the construction of antibody-drug conjugates. Nat Chem. 2016 Feb;8(2):114-9. |
溶解性:
DMSO : 24.5 mg/mL (31.77 mM; Need ultrasonic and warming) |
保存條件:
-20℃ |
配置溶液濃度參考:
|
1mg |
5mg |
10mg |
1 mM |
1.297 ml |
6.485 ml |
12.969 ml |
5 mM |
0.259 ml |
1.297 ml |
2.594 ml |
10 mM |
0.13 ml |
0.648 ml |
1.297 ml |
50 mM |
0.026 ml |
0.13 ml |
0.259 ml |
|
注意: |
部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。 |