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Galanthaminone 99%

Galanthaminone

源葉(MedMol)
S85604
510-77-0
C17H19NO3
285.34
加蘭他敏;(4aS,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one; 3-Deoxy-3-oxo-galanthamine; Narwedine
品牌 貨號 產(chǎn)品規(guī)格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數(shù)量
源葉(MedMol) S85604-5mg 99% ￥768.00元 >10 - - -
源葉(MedMol) S85604-10mg 99% ￥1200.00元 >10 - - -
源葉(MedMol) S85604-25mg 99% ￥2880.00元 >10 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

產(chǎn)品描述：

Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
靶點(diǎn)： AChE
體外研究： Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.
體內(nèi)研究： Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.
參考文獻(xiàn)： 1. Greenblatt HM, et al. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463(3):321-6. 2. Heinrich M, et al. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92(2-3):147-62.
溶解性： soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 3.505 ml 17.523 ml 35.046 ml
5 mM 0.701 ml 3.505 ml 7.009 ml
10 mM 0.35 ml 1.752 ml 3.505 ml
50 mM 0.07 ml 0.35 ml 0.701 ml
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參考文獻(xiàn)

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摩爾濃度計算器

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