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TPI-1 98%

TPI-1

源葉(MedMol)
S86548
79756-69-7
C12H6Cl2O2
253.0808
品牌 貨號 產品規格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數量
源葉(MedMol) S86548-1mg 98% ￥210.80元 5 - - -
源葉(MedMol) S86548-2mg 98% ￥380.80元 5 - - -
源葉(MedMol) S86548-5mg 98% ￥680.00元 5 - - -
源葉(MedMol) S86548-10mg 98% ￥1156.00元 6 - - -
源葉(MedMol) S86548-25mg 98% ￥1600.00元 4 - - -
源葉(MedMol) S86548-50mg 98% ￥2750.00元 預計交期：2-3天 - - -
源葉(MedMol) S86548-100mg 98% ￥4000.00元 預計交期：2-3天 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM
產品描述： TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM
靶點： IC50: 40 nM (recombinant SHP-1);Phosphatase;GlucocorticoidReceptor
體外研究：
SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ+ cells and induces IFNγ+ cells in human peripheral blood
體內研究：
TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ+ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent
參考文獻：
1. Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36.
溶解性： soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 3.951 ml 19.757 ml 39.513 ml
5 mM 0.79 ml 3.951 ml 7.903 ml
10 mM 0.395 ml 1.976 ml 3.951 ml
50 mM 0.079 ml 0.395 ml 0.79 ml
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參考文獻

質檢證書(COA)

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摩爾濃度計算器

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