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  1. 首頁(yè) > 小分子化合物 > 信號(hào)通路 > PI3K/Akt/mTOR 信號(hào)通路 > NIH-12848

NIH-12848 98%

NIH-12848

源葉(MedMol)
S88761
959551-10-1
C20H14F3N3S
385.41
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫(kù)存（上海） 北京 武漢 南京 購(gòu)買(mǎi)數(shù)量
源葉(MedMol) S88761-2mg 98% ￥382.50元 5 - - -
源葉(MedMol) S88761-5mg 98% ￥595.00元 6 - - -
源葉(MedMol) S88761-10mg 98% ￥935.00元 8 - - -
源葉(MedMol) S88761-25mg 98% ￥1480.00元 6 - - -
源葉(MedMol) S88761-50mg 98% ￥2350.00元 預(yù)計(jì)交期：2-3天 - - -
源葉(MedMol) S88761-100mg 98% ￥4200.00元 預(yù)計(jì)交期：2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(shū)(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.
產(chǎn)品描述： NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.
靶點(diǎn)： IC50: 1 μM (PI5P4Kγ);PI3K
體外研究：
NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks
參考文獻(xiàn)：
1. Clarke JH, et al. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Biochem J. 2015 Mar 1;466(2):359-67.
溶解性： Soluble  in  DMSO
保存條件： -20°C
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.595 ml 12.973 ml 25.946 ml
5 mM 0.519 ml 2.595 ml 5.189 ml
10 mM 0.259 ml 1.297 ml 2.595 ml
50 mM 0.052 ml 0.259 ml 0.519 ml
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參考文獻(xiàn)

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