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  1. 首頁 > 動(dòng)物造模試劑 > 神經(jīng)系統(tǒng)造模 > 帕金森模型 > 6-Hydroxydopamine Hydrochloride

6-Hydroxydopamine Hydrochloride

    
98%

6-Hydroxydopamine Hydrochloride

源葉(MedMol)
S88807 一鍵復(fù)制產(chǎn)品信息
28094-15-7
C8H12ClNO3
205.64
6-羥基多巴胺鹽酸鹽;2,4,5-三羥基苯乙胺鹽酸鹽;2,5-二羥基酪胺鹽酸鹽;6-羥基多巴胺鹽酸鹽;鹽酸-2,4,5-三羥基苯乙胺;鹽酸-6-羥基多巴胺;6-羥基多巴胺(H4381);6-羥基多巴胺合氯化氫;5-(2-氨基乙基)-1,2,4-苯三酚鹽酸鹽;6-Ohda;6-Hydroxydopamine Hydrochloride;2,4,5-Trihydroxyphenethylamine H
貨號(hào) 規(guī)格 價(jià)格 上海 北京 武漢 南京 購買數(shù)量
S88807-5mg 98% ￥100.00 6 - - -
S88807-10mg 98% ￥168.00 6 - - -
S88807-25mg 98% ￥260.00 7 - - -
S88807-50mg 98% ￥480.00 3 - - -
S88807-100mg 98% ￥900.00 1 - - -
產(chǎn)品介紹 參考文獻(xiàn)(2篇) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome

產(chǎn)品描述： Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrochloride is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrochloride promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrochloride can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome
靶點(diǎn)： COX-2;IL-1β;Caspase-3;Caspase-8;Caspase-9
體內(nèi)研究： Oxidopamine hydrochloride (5 μg/2 μL, unilaterally injected into the right striatum) induces degeneration of dopaminergic neurons in substantia nigra of rats
參考文獻(xiàn)： 1. Kang X, et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459. 2. Jin F, et al. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. Eur J Pharmacol. 2008 Dec 14;600(1-3):78-82. 3. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23. 4. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12.
溶解性： Soluble  in  DMSO、H2O
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 4.863 ml 24.314 ml 48.629 ml
5 mM 0.973 ml 4.863 ml 9.726 ml
10 mM 0.486 ml 2.431 ml 4.863 ml
50 mM 0.097 ml 0.486 ml 0.973 ml
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質(zhì)檢證書(COA)

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摩爾濃度計(jì)算器

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