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CaCCinh-A01 98%

CaCCinh-A01

源葉(MedMol)
S89027
407587-33-1
C18H21NO4S
347.43
品牌 貨號 產品規格 價格(RMB) 庫存（上海） 北京 武漢 南京 購買數量
源葉(MedMol) S89027-5mg 98% ￥400.00元 6 - - -
源葉(MedMol) S89027-25mg 98% ￥1440.00元 4 - - -
源葉(MedMol) S89027-100mg 98% ￥3840.00元 4 - - -
產品介紹 參考文獻 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC50s of 2.1 and 10 μM, respectively.
產品描述： CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC50s of 2.1 and 10 μM, respectively.
靶點： IC50: 2.1 μM (TMEM16A), 10 μM (CaCC);Chloridechannel
體外研究：
30 μM CaCCinh-A01 and 100 μM tannic acid strongly inhibit CaCC current following ATP stimulation[1]. Calcium-dependent chloride current is reduced by 38±14, 66±10, and 91±1% by 0.1, 1, and 10 μM CaCCinh-A01, respectively. ATP-induced short-circuit currents are reduced by 38±7 and 78±3% at 10 and 30 μM CaCCinh-A01, respectively
體內研究：
CaCCinh-A01 (vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion) significantly reduces infarction when compared with MCAO-saline treatment at 24 h or 72 h in middle cerebral artery occlusion model in mice. Animal Model: Two-month-old male C57/BL6J mice Dosage: 5 mg/kg Administration: Vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion Result: Attenuated brain infarct size, improved neurological outcomes and lowered BBB permeability after ischemic stroke in mice.
參考文獻：
1. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloridechannel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21;286(3):2365-74. 2. De La Fuente R, et al. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloridechannel. Mol Pharmacol. 2008 Mar;73(3):758-68. 3. Pin-Yi Liu, et al. TMEM16A Inhibition Preserves Blood-Brain Barrier Integrity After Ischemic Stroke.Front Cell Neurosci. 2019 Aug 6;13:360.
溶解性： Soluble  in  DMSO
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.878 ml 14.391 ml 28.783 ml
5 mM 0.576 ml 2.878 ml 5.757 ml
10 mM 0.288 ml 1.439 ml 2.878 ml
50 mM 0.058 ml 0.288 ml 0.576 ml
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參考文獻

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摩爾濃度計算器

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